Jesus' friends and family think he is out of his mind. If you read the entire passage, what follows is Jesus' explanation of why he is not crazy or of the devil. His miracles and public ministry were so new and amazing, people were scared. He didn't conform with the societal norms. His words and deeds were 'outside the box'. He was different.
One more thing: When you are different, you call attention to yourself. Do you ever feel you come under criticism for trying to raise your family with Christian values? Are you accused of being a 'fuddy-duddy' mom because you don't let your children listen to today's music or dress like a rock star? Does your own family call you crazy? Jesus knows how that feels. Nobody's opinion was going to change Jesus. He had to answer to God the Father for his actions, and so do I. So when I feel a little 'different', I just remember I'm in good company!
Prayer: Heavenly Father, help me to always be faithful to you and your calling, no matter what people think. Give me the strength and courage to live a life for you. In Jesus' name I pray, Amen. St. Vincent, pray for me.